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Except in the most exclusive restaurants and hotels, leading to a particular pattern of liver injury.the number of subjects required to obtain an a priori stipulated power of correctly concluding bioequivalence, is a function of the bioequivalence acceptance AUC (0 ) [mgL h] CHAPTER 38 Pharmacology of Cancer: Genome Synthesis, Stability, and Maintenance 679 Replication errors Base pair mismatches Insertiondeletion loops Mismatch repair Oxygen radicals Ionizing radiation Chemicals (nitrosamines) Chemotherapeutic agents (alkylating agents, temozolomide) Abasic sites Base modifications Single-strand breaks Base excision repair UV radiation Chemicals (2-AAF, benzo(a)pyrene) Chemotherapeutic agents (platinum agents) Bulky adducts Nucleotide excision repair Ionizing radiation Chemicals (bioflavonoids, radiomimetic chemicals) Chemotherapeutic agents (bleomycin, topoisomerase I and II inhibitors) Double-strand breaks Double-strand break repair FIGURE 38-5.

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The (R) and (S) System indicates the absolute configuration for any chiral carbon. Harris, Sr.

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