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57) (The arrow indicates that the derivative acts on the function on the left μ of the operator, i. Polyubiquitination of target proteins results in their recognition by the 26S proteasome, which consists of a 19S outer regulatory subunit and a 20S internal core chamber.

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To facilitate the cleavage of this bond, enzymes such as methylmalonyl CoA mutase displace the benzamidazole group from the cobalt and coordinate the cobalamin through a histidine residue (Figure 22.

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